World Ovarian Cancer day is celebrated on May 8th each year to save lives by
increasing the awareness about this deadly disease.
Ovarian
cancer has got the lowest survival rate and often diagnosed at very late stage
among all gynecological malignancies. Ovarian Cancer day was first celebrated
on May 8th, 2013 when cancer organization all around the world came together to
educate the women about symptoms and signs of this malignancy.
Some facts
about Ovarian Cancer:
Ovarian
cancer is the seventh most common cancer in women worldwide (18 most common
cancer overall), with 239,000 new cases diagnosed in 2012.
It is
responsible for 140,000 deaths each year. Statistics show that just 45% of
women with ovarian cancer are likely to survive for five years compared to up
to 89% of women with breast cancer.
Fiji had the
highest rate of ovarian cancer, followed by Latvia and Bulgaria.
The
five-year prevalence of women globally living with ovarian cancer is 22.6 per
100,000.
Risk factors
for developing ovarian cancer:
Age > 55
years, family history, known carrier of abnormalities in the BRCA1 or BRCA2
genes, Nulliparity, never taken the contraceptive pill, long reproductive life span
(early menarche and late menopause) and history of endometriosis.
Screening:
There is no
“standard” screening test for asymptomatic, low-risk patients, and the only
patient populations that should be recommended for ovarian cancer screening are
patients with known BRCA germline mutations and women with family members who
have had ovarian cancer or breast cancer.
Two common
screening tests for high-risk patients include pelvic ultrasound and checking
CA 125 levels. But CA 125 is elevated in only 50 percent of stage I ovarian
cancers, and many other conditions can falsely elevate the levels, including
endometriosis, liver disease and post abdominal surgery. Following a positive
screening test, a diagnostic test is required. False positive tests lead to an
increase in complications compared to usual follow up. In fact, there are no
studies that show screening for ovarian cancer improves survival.
Symptoms:
Ovarian
cancer does not have any early symptoms. Often the symptoms are common to other
less serious conditions and are often overlooked.
Awareness
about risk factors and family/genetic history is the key to clinch the
diagnosis at early stage.
If a women
experiences following symptoms on most days within a three-week period, she
should be investigated: Change in
bowel habits, frequent bloating, feeling full very quickly, abdominal or pelvic
pain and increased urgency/frequency of urination.
Check out
this excellent video by AstraZeneca on World Ovarian Cancer Day.
As mentioned in the text endometriosis predisposes to ovarian Ca, then should we be more in favour of removal of ovaries if someone have completed family, aged > 45 yrs and is still is on medical management for long lasting endometriosis?
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