Women with
polycystic ovarian syndrome (PCOS) have 8.64 fold increase in risk of developing
premature ovarian failure as compared to women who did not have PCOS according
to a population based study in forthcoming issue of Journal Menopause.
The study
authors reviewed data across a period of 14 years (1998 to 2012) from Taiwan
National Health Insurance Research Database.
The study
group consisted of women with PCOS (exposure group; n=7,049), each woman with
PCOS was age matched with 10 other women without PCOS. (contrast group; n =
70,490).
The cohort
was followed up for 10 years. The diagnosis of POI and PCOD was confirmed by
blood test and ultrasonography.
Polycystic
ovary syndrome (PCOS) is an endocrinopathy that affects approximately 10% of
reproductive-aged women throughout their lives and POI affects 1-3% of women by
age 40.
It was seen
that POI was nearly 8 times more common in women with PCOD. Kaplan-Meier
survival analysis showed that POI free survival rates of women were
significantly more in contrast group than exposure group (P < 0.001).
After
adjustment of covariates, it was seen that women with PCOD have 8.31 fold
increase in risk of developing premature ovarian failure, this was 9.93 fold for
women who did not receive metformin treatment for PCOS.
Metformin
was significantly effective in lowering the risk to nearly half (5.66).
However,
well-designed, prospective, long-term, large-scale, randomized clinical trials
are necessary to elucidate the efficacy and safety of long term metformin in
patients with PCOS.
The results
of this study are in contrast to the earlier hypothesis that women with
polycystic ovaries (PCO) are protected against POI because they may have
actually been born with a larger pool of resting follicles.
Currently,
PCOS and POI are both being investigated as diseases of autoimmune origin.
Not all women suffering from PCOS syndrome do have demonstrate autoimmune markers neither all PCOS women is going to have POI (POF-DOR). I intend to know A) can we forecast who are going to have POI at an early age-thereby enabling s to counsel the woman concerned. B) What are the dynamics (etiopathology of early follicular depletion) in some cases of PCOS leading to POI? C) Additionally, should clinicians and women suffering from PCOS will consider POI as a boon as she is relived of Mens irregularities or say Menorrhagia?? D) Further in view of hyperoestrogenic sate induced by obesity in PCOS women -- what will be most preferred and safe HRT if she becomes a victim of POI (DOR)? Choice of HRT to protect bone health & Cardiac health?-Dr S K Pal. Kolkata, India
ReplyDeleteNice post...
ReplyDeletePolycystic Ovarian Disease is condition of infertility in women. Due to this disorder, some problems occurs.
PCOD and PCOS are often used interchangeably. However, there is a difference between PCOD and PCOS is the milder form where the symptoms are mainly limited to ovaries and reproductive system. Whereas, PCOS is an advanced form, where the symptoms occur throughout the body in terms of weight gain, facial hair growth, acne, hair loss along with the menstrual irregularities. PCOS requires correct treatment, modification of diet, and lifestyle. Click on more detail.
ReplyDeleteDifference between PCOD and PCOS
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ReplyDeleteI have been suffering from Polycystic Ovary Syndrome (PCOS) since my 20 years of age. Ever since i got married i have not been able to get pregnant, so i was completely barren due to this genetic disorder. I was prescribed several Clomid Meds but couldn't see any improvement. I would basically go from one outbreak to the next. Finally, on my best friend's recommendation about Dr James herbal mix medicine who cures all kinds of diseases with his herbal medicine, I decided to try his herbal remedy which is made in liquid form with natural roots and herbs from Dr James. Within a few weeks, I could see improvements in the symptoms.
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