Showing posts with label NAMSNeurokinin 3 (NK3). Show all posts
Showing posts with label NAMSNeurokinin 3 (NK3). Show all posts

Sunday, August 20, 2017

Clinical review: Updates on Menopause


Here is a roundup of the latest research on Menoapuse.

In this article:

Early menopause ups the risk of developing type 2 diabetes
Women who have an early natural menopause have 2.5 times the risk of developing type 2 diabetes as compared to women who have normal menopause reports the results of a large population based study published online July 18, 2017 in Journal Diabetologia.

Oophorectomy during premenopausal hysterectomy: Evaluating the prevalence
Nearly 1 in 3 women undergo oophorectomy during premenopausal hysterectomy in absence of appropriate indication, reports a study published ahead of print May 8, 2017 in North American Menopausal Society (NAMS) journal Menopause.

Loss of estrogen in postmenopausal women puts them at high risk for lumbar disc degeneration.
Declining estrogen levels during perimenopausal and menopausal years is associated with severe lumbar disc degeneration reports a study published online June 12, 2017 in journal Menopause, the journal of The North American Menopause Society (NAMS).

ACP updates guideline for treating Osteoporosis.
According to International Osteoporotic Foundation (IOF), 1 in 3 women over age 50 will experience osteoporotic fractures and nearly 200 million women suffer from osteoporosis worldwide.

Polycystic ovarian syndrome increases the risk of subsequent early ovarian aging later in life.
Women with polycystic ovarian syndrome (PCOS) have 8.64-fold increase in risk of developing premature ovarian failure as compared to women who did not have PCOS according to a population based study in forthcoming issue of Journal Menopause. Metformin was found to be effective in reducing such risk.

New natural (bioidentical) 17ß-estradiol-progesterone combination available as single soft gel capsules effective in treating postmenopausal symptoms: News from ENDO17
An innovative, investigational combination of 17ß-estradiol and progesterone in a single, oral softgel, was found effective for the treatment of moderate to severe vasomotor symptoms (VMS) due to menopause. The results of the study were presented at the ENDO 2017, the annual meeting of the Endocrine Society in Orlando, Florida, April 1-4.
New class of drug effective in targeting menopausal symptoms: News from Endocrine Conference 2017.
A new class of drug Neurokinin 3 (NK3) receptor antagonists is highly effective and low risk alternative to hormone replacement therapy(HRT) for treatment of menopausal hot flashes according to a study presented at the ENDO 2017, The endocrine society annual meeting from April 1–4, 2017, in Orlando, FL.

Menarche ≤11 years and Nulliparity is a risk factor for Premature and Early Menopause.
Women who had their first period at or before the age of 11 are at increased risk for premature and early menopause and the risk is further amplified if the woman is nulliparous according to a large observational study published on January 25, 2017 in Oxford Journal of Human Reproduction.




Saturday, April 15, 2017

Here are the top 5 posts this week.


Sperms used as vehicle for targeted drug delivery in gynecological cancers.
Sperms are not just for baby-making anymore, but can be used as cargo agents for delivering drugs inside the body.
Researchers at Institute for Integrative Nanosciences in Germany and Chemnitz University of Technology are working on innovative way to use sperms as cargo delivery agents to carry drugs through female reproductive tract.


New class of drug effective in targeting menopausal symptoms: News from Endocrine Conference 2017
A new class of drug Neurokinin 3 (NK3) receptor antagonists is highly effective and low risk alternative to hormone replacement therapy(HRT) for treatment of menopausal hot flashes according to a study presented at the ENDO 2017, The endocrine society annual meeting from April 1–4, 2017, in Orlando, FL.
NK3 receptor blockers fezolinetant (Ogeda) and MLE4901 (Millendo Therapeutics) were found useful in reducing moderate to severe hot flashes in postmenopausal women. 


New natural (bioidentical) 17ß-estradiol-progesterone combination available as single soft gel capsules effective in treating postmenopausal symptoms: News from ENDO17
An innovative, investigational combination of 17ß-estradiol and progesterone in a single, oral softgel, was found effective for the treatment of moderate to severe vasomotor symptoms (VMS) due to menopause. The results of the study were presented at the ENDO 2017, the annual meeting of the Endocrine Society in Orlando, Florida, April 1-4.

23andMe receives FDA clearance for at home risk testing for 10 genetic diseases.
23andMe become the first ever company that receives FDA clearance for offering consumers at home genetic risk testing for 10 diseases or condition. This is the first direct-to-consumer (DTC) authorization by FDA so that people may know about their genetic predisposition to certain conditions and make lifestyle choices in consultation with health care providers.
Up Till now patients who wanted to get the genetic test done has to see a Physician to order the tests.


North American Menopause Society (NAMS) video series about important midlife health topics: April 2017.
In this monthly series, the latest video is “treatment for perimenopause and postmenopausal bleeding” Dr. Goldstein discusses what action must be taken for spotting, staining, or bleeding for perimenopausal and postmenopausal women.