Sunday, November 26, 2017

ACOG updates the practice advisory for influenza vaccination during pregnancy



The American congress of obstetrics and gynecologists(ACOG) has issued a recent practice advisory for influenza vaccination during pregnancy.

A recent case -control study published in September issue of journal Vaccines linked spontaneous abortion and receipt of influenza vaccine in first trimester of pregnancy. In this case control study women had nearly twice the odds of experiencing a miscarriage if they were vaccinated in the preceding 28 days period. (OR 2.0; 95% CI 1.1–3.6)

The odds of spontaneous miscarriage were further increased 7 times if the women also received the pH1N1-containing vaccine in the previous influenza season. (OR 7.7; 95% CI 2.2–27.3)
Once the 28 days window is passed, not increased chances of spontaneous pregnancy loss was observed.

The same study also observed no adverse effects or pregnancy loss when vaccination was given either later in the first trimester or in the second or third trimester.

Hence, ACOG reviewed the evidence by evaluating all the scientific information available and concluded that this study had some limitations and does not establishes causality. It also calls for additional studies and clinical trials before the concern is fully addressed.

ACOG still affirms it stand of vaccinating every pregnant woman with a flu shot, irrespective of the trimester she is in.

For many years, ACOG and the CDC have recommended that every pregnant woman receive a flu shot during any trimester.






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