A short inter-pregnancy
interval of less than 3 months after a pregnancy loss, increases the chances of
successful future pregnancy according to results of small study published electronically ahead of print in journal obstetrics and gynecology.
The study
was also presented at the Society for Reproductive Investigation's 64th Annual
Meeting, March 15–18, 2017, Orlando, Florida. (Abstract- O-095)
There is no uniform
consensus about the optimal pregnancy interval after a miscarriage. Some physician
advising no delay, others advising a gap of at least 3 months, while the WHO
guidelines recommending at least six months.
This prospective
cohort study recruited 514 women over a period of 2 years (2010-2012), who have
suffered a spontaneous pregnancy loss in their most recent pregnancy. The median
maternal age was 30 years and nearly half of the women had a previous live
birth.
The inter-pregnancy
interval were modeled against risk of miscarriages, after adjusting for age, parity,
race and BMI.
Nearly 15
suffered a repeat pregnancy loss(n=81), and women with longest interpregnancy interval
of 1 – 1.5 years had a 20% chance of repeat miscarriages as opposed to 7%
chance in women whose conceived again within 3 months of the miscarriage (adjusted
HR 0.33, 95% CI 0.16–0.71).
The drawback
of the study was its small sample size.
The authors
concluded that, “Contrary to guideline recommendations, we found that IPIs
after pregnancy loss of less than three months are associated with the lowest
risk of subsequent miscarriage for the first time in a prospective pregnancy
cohort. This implies that counseling women to delay conception in the clinic
may not be warranted.”
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