Preconception Impaired Glucose Tolerance (IGT)
in women with Polycystic Ovarian Syndrome (PCOS), is associated with adverse
pregnancy as compared to women with normoglycemia or isolated impaired fasting
glucose (i-IFG) reports the results of multi-center randomized trial published ahead of print in the Endocrine Society’s Journal of Clinical Endocrinology
& Metabolism.
These
results were independent of prepregnancy BMI.
PCOS is prevalent
in 7-8% of women of childbearing age and it is the most common cause of
infertility. This study was also a secondary analysis of data from RCT that was
designed to compare the obstetric outcomes between fresh and frozen embryo
transfer.
Baseline
fasting and 2-hour glucose and insulin levels following 75-g OGTT were measured
in 1508 women with PCOS.
Women who
had IGT before they become pregnant faced 3 times and 8 times increased odds of
developing Gestational Diabetes in singleton pregnancy and twin pregnancy respectively.
These women
also faced twice the risk of large for gestational age babies and singleton pregnancy
loss as compared to women with normal blood sugar levels. All these
associations were true even after the data was adjusted for confounder like age,
body mass index (BMI), duration of infertility, total testosterone level, and
treatment groups (frozen vs. fresh embryo transfer).
The
researchers concluded that preconception impaired glucose tolerance is
associated with adverse pregnancy outcomes in women with PCOS.
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