Wednesday, August 16, 2017

ACOG releases Committee Opinion for Prenatal Corticosteroid Therapy for Fetal Maturation


An updated committee opinion from the American College of Obstetricians and Gynecologists (ACOG), was published in the August issue of Obstetrics & Gynecology.

Liggins and Howie published their landmark paper in 1972, that showed the benefits of single course of antenatal corticosteroid therapy administered to women at risk for preterm delivery in reducing RDS and mortality in offspring.

Since then countless trials have confirmed these findings and also shown that timely steroid administration reduces rates of intraventricular hemorrhage (IVH) and necrotizing enterocolitis.

An updated ACOG opinion published in October 2016 issue, expanded the use of steroids in women at high risk for late preterm birth (34 0/7 - 36 6/7 weeks).

The current recommendations are:

A single course of corticosteroids is recommended for pregnant women between 24 0/7 weeks and 33 6/7 weeks of gestation who are at risk of preterm delivery within 7 days, irrespective of intact or ruptured membranes and single or multiple gestations.

It could also be given at 23 0/7 weeks of gestation to women at risk of preterm delivery with 7 days based on discussion with family members regarding resuscitation of the newborn.

A decision to administer corticosteroids during the peri viable period (20 0/7 weeks to 25 6/7 weeks of gestation) should always be based on discussions with the patients and family members regarding resuscitation of the newborn.

A single course of betamethasone is recommended for pregnant women at risk of preterm birth between 34 0/7 weeks and 36 6/7 weeks of gestation, provided they have not received a previous course of antenatal corticosteroids.

A single repeat course can be given to women who are less than 34 0/7 weeks of gestation who are at risk of preterm delivery within 7 days, whose previous course was administered more than 14 days earlier and in some clinical scenarios 7 days earlier.

Repeated or serial administration of more than 2 doses is not recommended.

At present, no recommendation can be made for a repeat or rescue dose of corticosteroids in patients with preterm prelabor rupture of membranes (PROM).

ACOG also recommends long term follow up and surveillance of babies who received in utero corticosteroids administration.

It also advocates ongoing development of strategies to support timely administration of corticosteroids to women at risk of delivering with 7 days and avoid overuse in low risk patients.

The committee opinion full text can be accessed here.


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