Showing posts with label ovarian transposition. Show all posts
Showing posts with label ovarian transposition. Show all posts

Saturday, March 18, 2017

Here are the top 5 posts this week.

Ovarian Transposition: A novel laparoscopic surgical method video by Cleveland Clinics.
A recent article published in forthcoming issue of Fertility and Sterility describes and demonstrate novel surgical method of laparoscopic ovarian transposition. This is a minimal invasive approach in which the ovary is tunneled through a peritoneum.

Treating Hypothyroidism and hypothyroxinemia in pregnancy? Clinical dilemma continues.
Treating antenatal patients with levothyroxine who have hypothyroidism or hypothyroxinemia between 8 to 20 weeks of pregnancy did not result in better cognitive outcome and IQ in children through 5 years of age as compared to women who received placebo.
The study was published online on March 2, 2017 in the New England Journal of Medicine.

Vitamin B, a personal weapon to mitigate the effects of Air Pollution.
Vitamin B could attenuate the effects of most dangerous type of air pollution and could be used at personal level to protect against the ill effects. The study was recently published in Proceedings of the National Academy of Sciences of the United States of America.

Wow, new paper based test can tell your blood group in 30 seconds!
Researchers working at the Third Military Medical University in Chongqing, China have developed a quick and reliable test to know the blood type in seconds and rapidly determine the compatibility of donor and recipient blood samples before transfusion.

CRISPR co-inventor Jennifer Doudna keynote address about responsible use of gene editing in future.
“What if a cell’s DNA could be edited just like the text of a document so that you could actually erase letters, you could erase whole sentences, [you could] replace sentences, and you could do things that would enable scientists to change the mutations that might cause genetic disease, make changes that allow us to understand the function of DNA and different kinds of organisms and perhaps, enable us to really direct the way that organisms are evolving on the planet?”
With this promising words about future of CRISPR Cas9 technology Jennifer Doudna, co-inventor of CRISPR Cas9 technology started her keynote address at 2017 South by Southwest (SXSW) conference.


Friday, March 17, 2017

Ovarian Transposition: A novel laparoscopic surgical method video by Cleveland Clinics.

First described in 1958, ovarian transposition is a great way to move ovaries away from the radiation field to preserve fertility and prevent early menopause in reproductive age women undergoing pelvic or low abdominal radiation therapy. These women may also be scheduled to receive chemotherapy, which has low gonadotoxicity after the radiation therapy.

The vascular pedicle remains intact in transposition vs. transplantation. Ovarian stimulation and oocyte retrieval can be easily performed later when the patient desires fertility.  

Oocytes are highly sensitive to radiation and 16 gray (Gy) of radiation will deplete the entire oocyte pool in a 20-year-old.

The most common cancers which require low abdominal radiations are rectal and anal cancers.

A recent article published in forthcoming issue of Fertility and Sterility describes and demonstrate novel surgical method of laparoscopic ovarian transposition. This is a minimal invasive approach in which the ovary is tunneled through a peritoneum.

A 29-year-old female was diagnosed with rectal cancer, the patient underwent laparoscopic ovarian transposition of one ovary followed by ovarian decortication for ovarian tissue freezing of the contralateral ovary, both performed in one laparoscopic surgery, before further chemotherapy and radiation.

The procedure was performed to maintain the ovarian blood supply retroperitoneally and prevent the ovarian vessels taking a sharp turn in pelvic cavity.  

The laparoscopic ovarian transposition has a success rate of 88.6% for preservation of ovarian function as seen from the levels of gonadotropin levels after cancer treatment.

A systematic review and meta-analysis of published in Journal of Ovarian Research concluded that it significantly preserves ovarian function with minimum risk of metastasis to the ovary even in gynecological malignancies.


Here is the video presentation of the surgical procedure by Cleveland Clinics.