Showing posts with label breast. Show all posts
Showing posts with label breast. Show all posts

Thursday, November 30, 2017

CDC links overweight and obesity to increased risk of 13 different cancers


CDC recently released ‘vital signs’ have reported that being obese or overweight puts you at increased risk of 13 different cancers. These cancers constitute about 40% of all burden of cancer incidence in US. In 2014, approximately 631,000 persons in the United States received a diagnosis of a cancer associated with overweight and obesity.

Endometrial, ovarian, and postmenopausal female breast cancers accounted for 42% of new cases of overweight-and obesity-related cancers in 2014.

A review of data from 2005-2014 revealed that incidence of many of these cancers have increased by 7% in last 10 years, except colorectal cancers. Nearly 30% of US adult weigh more than what’s recommended and 50% do not have any idea that being overweight puts them at risk for these cancers.

CDC fact sheet
The obesity related cancers are adenocarcinoma of the esophagus, cancers of the breast [in postmenopausal women], colon and rectum, endometrium, gallbladder, gastric cardia, kidney, liver, ovary, pancreas, and thyroid; meningioma; and multiple myeloma.

On the other hand, non-obesity related cancers are down by 13%.

These obesity related cancers constitute nearly half of all the cancers in women and quarter of all cancers in men.

This finding has important public health implications as the burden can be considerably reduced by making a change in lifestyle and behaviors.

Multiple level interventions into policy, systems, and environmental changes that promote physical activity and healthy food options in communities

The CDC’s National Comprehensive Cancer Control Program supports comprehensive cancer control efforts, including environmental approaches that promote physical activity and healthy food options in communities.

To start with everyone can:
Eat a healthy diet by following the 2015-2020 Dietary Guidelines for Americans.
Do at least 150 minutes of moderate intensity physical activity, such as brisk walking, every week.
Talk to your primary healthcare provider about losing weight.


Thursday, March 2, 2017

Obesity linked strongly with 11 cancers including digestive, endometrial and breast cancer.



Results of a recent umbrella review published online in BMJ have provided strong evidence to support the association between excess body weight and 11 cancers that include G.I tract, endometrial and postmenopausal breast malignancies.


“The association is now clear; it’s time to get serious about prevention, “write Professors Yikyung Park and Graham A Colditz in an accompanying editorial.

An Umbrella review is the reviews of existing systematic reviews and only considers the highest level of evidence to be included, namely systematic reviews and meta-analysis.[1] Hence, the findings from this umbrella review is the strongest evidence put forth so far linking obesity and cancer.

The study by Kyrgiou et al. initially selected 204 individual meta-analyses from 49 papers and further narrowed it down to 95 meta-analysis based on validity and association provided by the studies. 76% of the meta-analyses provided varied level of evidence for association between obesity and cancer.
  
The literature search was performed for meta-analysis and reviews that investigated association between adiposity indices and risk of developing or dying from any cancer. Adiposity indices included in the study were body mass index, waist circumference, hip circumference, waist to hip ratio, weight, weight gain, and weight loss from bariatric surgery.  Obesity was defined as a body mass index (BMI) >30 kg/m2.

The nine obesity related cancers with strong evidence were endometrial cancer (premenopausal women), breast cancer (postmenopausal), kidney cancer, multiple myeloma, esophageal adenocarcinoma, colon and rectal cancer (in men), biliary tract system and pancreatic cancer. The risk of ovarian and stomach cancer increases as the weight increases with maximum risk in obese vs. normal weight individuals.

The BMI was measured as a continuous variable.

With every 5 units increase in BMI, the risk of developing rectal cancer increased by 9% in men and that of developing biliary tract cancers increased by 56%.

For each 5 kg of weight gain in adulthood the risk of postmenopausal breast cancer increased by 11% even if the women have never used HRT, similarly for .1 increases in waist to hip ratio the risk of endometrial cancer increased by 21%.

Obesity has become a major public health problem in last four decades with the incidence being doubled among women and tripled among men. And preventing adult weight gain can bring down the risk of these cancers.

The authors also stressed the importance of primary care physicians in medical practice because they are the primary point of contact with the patients. They said “Given the critical role of healthcare providers in obesity screening and prevention, clinicians, particularly those in primary care, can be a powerful force to lower the burden of obesity related cancers, as well as the many other chronic diseases linked to obesity such as diabetes, heart disease, and stroke.”

Although more prospective studies are needed to confirm the association, personalized primary preventive strategies could be designed in subjects at ‘ high risk’ for cancers.  

Link to Editorial here