In case you missed it: Here are the top 5 posts this month

Finally, an oral drug found effective in treatment of Uterine Fibroids following successful phase-3 trial

Relugolix successfully reduced heavy menstrual blood loss among Japanese women in a Multicenter, Randomized, Double-Blind, Parallel-Group, Phase 3 Study to Evaluate the Efficacy and Safety of Oral relugolix 40 mg as compared with injectable leuprolide  in the Treatment of Uterine Fibroids.

Relugolix is an oral, once-daily, small molecule GnRH receptor antagonist that has been evaluated in almost 1,600 study participants in Phase 1, Phase 2 and Phase 3 clinical trials. In these trials, it has shown to suppress estrogen and progesterone levels in women and testosterone levels in men. (It is also being evaluated in advanced prostate cancer via ongoing phase-3 HERO study).

https://obgynupdated.blogspot.com/2017/10/finally-oral-drug-found-effective-in.html

Now ‘Switch’ the way you suture: Reinventing suturing technique with the new device

Mellon Medical, a Dutch MedTech developer has reinvented suturing by developing a device which enables the surgeon to suture with only one hand, the other hand remaining free to use as needed. The product is named Switch®, a single use precision instrument that allows the surgeon to suture tubular structures or skin with twice the speed of conventional suturing.

https://obgynupdated.blogspot.com/2017/10/now-switch-way-you-suture-reinventing.html

ACOG updates its guidelines on LARC

The American College of Obstetricians and Gynecologists (ACOG) today updated its guidelines on Long-Acting Reversible Contraception(LARC): Implants and Intrauterine Devices. These updated guidelines were published online October 24 in Obstetrics & Gynecology and replaces the old practice bulletin published in July 2011.

https://obgynupdated.blogspot.com/2017/10/acog-updates-its-guidelines-on-larc.html

ACOG updates guidance on postpartum hemorrhage- calls for standard, coordinated, protocol based intervention

The American College of Obstetricians and Gynecologists (ACOG) recently released expanded guidelines for management of postpartum hemorrhage (PPH)—the leading cause of maternal mortality worldwide.

PPH is defined as total blood loss of 1000 ml or more along with signs or symptoms of hypovolemia within 24 hours after the labor, but can occur up to 12 weeks postpartum. Although Maternal Mortality Rates(MMR) have decreased worldwide in last 4 decades, it still accounts for 10% of all pregnancy related mortality.

https://obgynupdated.blogspot.com/2017/10/acog-updates-guidance-on-postpartum.html

Endometriosis fertility index can accurately predict a women’s chances of conception after laparoscopy

The Endometriosis fertility index can accurately predict the possibility of non-ART conception or the need of ART for achieving pregnancy after surgical resection of moderate-severe (Stage III–IV) endometriosis reports the results of study published in Human Reproduction. The study confirmed that adnexal function is deciding factor in evaluation of fertility prognosis after the surgery.

There is no evidence based guidelines about post-surgery fertility management of women who have undergone surgery for severe endometriosis. Physicians differ in their approach about the length of conservative treatment and that sometimes add years and causes unnecessary delays.

https://obgynupdated.blogspot.com/2017/10/endometriosis-fertility-index-can.html

In case you missed it: Here are the top 5 posts this month

September was a very busy month with lots of good research papers and systematic reviews published on various topics. We also saw many guidelines and recommendations updates from ACOG, ASRM and USPSTF. Here are the top 5 most read posts for the month of September.

USPSTF simplifies cervical cancer screening recommendations: Dual testing no longer advised

The US Preventive Services Task Force (USPSTF) has issued new draft recommendations for cervical cancer screening with a major change that it recommends either cervical cytology (CC) or high-risk HPV (hrHPV) test as a screening procedure every 3 years for women aged 30-65 years, and not both ( Grade A)  

https://obgynupdated.blogspot.com/2017/09/uspstf-simplifies-cervical-cancer.html

ACOG issues clinical practice guidelines for Gestational Diabetes Mellitus

The American College of Obstetricians and Gynecologists (ACOG) has issued clinical practice guidelines for the diagnosis and treatment of gestational diabetes mellitus (GDM).

Although prevalence of GDM is directly proportional to prevalence of type 2 DM in a given population, it is estimated that GDM accounts for 90% of cases diabetes in pregnancy. The prevalence of DM in pregnancy is around 6-9%.

https://obgynupdated.blogspot.com/2017/09/acog-issues-clinical-practice.html

ASRM guidelines update: Metformin alone is not the first line of treatment for ovulation induction in women with PCOS

Practice Committee of the American Society for Reproductive Medicine does not recommend Metformin alone for ovulation induction as a first line therapy in women with PCOS. The guidelines were published in Journal Fertility and Sterility Epub ahead of print.

Metformin is a biguanide used as an oral insulin lowering agent in type2 diabetes, but also used enthusiastically in women with PCOS because of shared pathophysiology of insulin resistance in both.

https://obgynupdated.blogspot.com/2017/09/asrm-guidelines-update-metformin-alone.html

Oral Nifedipine parallels IV hydralazine in lowering down BP in acute hypertensive emergency in pregnancy

Intravenous hydralazine and oral nifedipine both exhibit the same efficacy in lowering the blood pressure in acute hypertensive emergency of pregnancy reports the results of small randomized trial published online in journal American Journal of Obstetrics and Gynecology.

https://obgynupdated.blogspot.com/2017/09/oral-nifedipine-parallels-iv.html

Oral diclofenac potassium plus cervical lidocaine cream eases the pain during hysterosalpingography

Oral diclofenac potassium tab 30 minutes before hysterosalpingography (HSG) and cervical lidocaine cream 5% significantly relieves pain and eases patient anxiety during the procedure and for half an hour after reports the results of a randomized trial published in September issue of journal Fertility and Sterility.

https://obgynupdated.blogspot.com/2017/09/oral-diclofenac-potassium-plus-cervical.html 

In case you missed it: Here are the top 5 posts this month

Clinical review: Updates on Cesarean Section

A roundup of the latest research on Cesarean Section

https://obgynupdated.blogspot.com/2017/08/clinical-review-updates-on-cesarean.html

ACOG releases Committee Opinion for Prenatal Corticosteroid Therapy for Fetal Maturation

An updated committee opinion from the American College of Obstetricians and Gynecologists (ACOG), was published in the August issue of Obstetrics & Gynecology.

https://obgynupdated.blogspot.com/2017/08/acog-releases-committee-opinion-for.html

Vaginal cleaning before cesarean delivery significantly reduces infection: A Systematic Review and Meta-analysis.

A simple and inexpensive intervention of vaginal cleaning with an antiseptic solution before cesarean delivery brings down the rate of endometritis note the results of a Systematic Review and Meta-analysis published August 4 in Journal of Obstetrics and Gynecology.

https://obgynupdated.blogspot.com/2017/08/vaginal-cleaning-before-cesarean.html

Adjunct Metformin helps reversal of atypical endometrial hyperplasia

Adjunct metformin treatment help reversal of atypical endometrial hyperplasia (AEH) and improves overall survival in endometrial cancer reports the result of a systematic review and meta-analysis published ahead of print in Journal of Gynecologic Oncology.

https://obgynupdated.blogspot.com/2017/08/adjunct-metformin-helps-reversal-of.html

Society for Maternal-Fetal Medicine (SMFM) issues guidelines for HCV in pregnancy

The Society for Maternal-Fetal Medicine (SMFM) has issued guidelines for screening and management of Hepatitis C infection in pregnancy.  

The guidelines were published ahead of print in American Journal of Obstetrics and Gynecology.

https://obgynupdated.blogspot.com/2017/08/society-for-maternal-fetal-medicine.html

In case you missed it: Here are the top 5 posts this month.

News from ACOG 2017: Changing gloves before abdominal closure brings down the rate of wound infection by almost 50% in Cesarean Section.

Results of a randomized controlled trial presented at the ACOG 2017showed that changing the outer gloves before closing the abdomen decreases the wound complication of infection, cellulitis and dehiscence.

Wound infection after a cesarean section (CS) is a major cause of maternal morbidity, lengthy hospital stays and increased medical cost. The rate of surgical site infection after cesarean section range from 3% to 15%. 

https://obgynupdated.blogspot.com/2017/05/news-from-acog-2017-changing-gloves.html

CDC releases ‘long awaited’ guidelines for preventing surgical site infections.

The Center for Disease Control released it’s much awaited update to its 1999 guidelines for the prevention of surgical site infections (SSIs). The guidelines were published online May 3, 2017 in JAMA.

As the number of surgeries performed worldwide rise, so does the human and financial cost of treating this infection also rises as reimbursements for SSIs are often reduced or denied. It is estimated that 50% of SSIs are preventable.

https://obgynupdated.blogspot.com/2017/05/cdc-releases-long-awaited-guidelines.html

ACOG updates its recommendations for estimating gestational age and due date: May 2017

Accurate gestational dating of pregnancy is very important for optimal maternal and fetal outcome.Throughout pregnancy decisions like ordering and interpreting lab tests, determining fetal growth and performing intervention to prevent preterm births or post-term pregnancies and associated morbidities are based on accurate dating.

Estimated Due Date (EDD)and current gestational dating should be documented on medical records and discussed with the patient as early as possible based on dates of Last Menstrual Period(LMP) and earliest available ultrasound in pregnancy.

https://obgynupdated.blogspot.com/2017/05/acog-updates-its-recommendations-for.html

ACOG issues guidelines for obstetrics analgesia and anesthesia.

ACOG has issued clinical guidance for obstetricians and other healthcare professional for management of pain during labor and giving anesthesia for any surgical procedure required during labor.

The reviewed guidelines were published in Journal of Obstetrics & Gynecology, April issue.

https://obgynupdated.blogspot.com/2017/05/acog-issues-guidelines-for-obstetrics.html

Antenatal Corticosteroids administration just few hours before preterm delivery improves survival and health gains for the infants.

Imminent preterm labor, with no time to give antenatal corticosteroids? Still give it says the result of a large population based study.

Antenatal corticosteroids given few hours before an imminent delivery is effective in improving survival says results of a large population-based study of 4594 European infants born before 32 weeks’ gestation. This study was published on line today in JAMA Pediatrics.

https://obgynupdated.blogspot.com/2017/05/antenatal-corticosteroids.html