Showing posts with label ARTs. Show all posts
Showing posts with label ARTs. Show all posts

Friday, November 10, 2017

Consumption of pesticides treated fruits and vegetables linked with reduced fertility in women


Regular dietary consumption of fruits and vegetables treated with pesticides is linked to lower probability of live births and success rates of ARTs according to a study from Harvard T.H. Chan School of Public Health published October 30, 2017 in JAMA.

Animal exposure to pesticides at environmentally relevant concentrations is known to decrease the number of live births. Whether this holds good for humans is topic for research in recent years, the effects of high dose exposure causing reproductive injuries is already known.

More than 600 different pesticides chemicals, resulting into 1000s of combinations are available in US market with more than 450 kg applied every year.

Occupational exposure to high dose of some older pesticides are known to cause reproductive injury in exposed males causing infertility and azoospermia.

This prospective epidemiological study uses sophisticated biological markers to identify the effects of subclinical everyday exposure pesticide residues in fruits and vegetables on female fertility.

The study recruited 325 women undergoing infertility treatment as part of the Environment and Reproductive Health (EARTH) study. The women filled out study questionnaire about the daily consumption of fruits and vegetables. Women’s exposure to pesticides was calculated based on US government database of average pesticide residues on fresh fruits and vegetables.

The study found that women who ate more than two servings (2.3) of high-pesticide fruits or vegetables each day, compared with women who ate an average of one each day, were 18% less likely to become pregnant and 26% less likely to have a live birth than women with the lowest exposure.

If you can exchange one high-pesticide fruit or vegetable a day for a low-pesticide one, your odds of pregnancy are increased by 79% and live birth by 88% say the researchers.

Strawberries, spinach and peppers, tend to consistently make into the list of ‘dirty dozen’, a list of 12 most contaminated fruits and vegetables, while others, like peas and avocados, rank lower.

Jorge Chavarro, associate professor of nutrition and epidemiology at Harvard Chan School and senior author of the study, said that women trying to conceive may want to limit their intake of high-pesticide fruits and vegetables or eat organic versions, or choose low-pesticide produce such as avocados, onions, or oranges. “I am now more willing to buy organic apples than I was a few months ago,” he told TIME.

When the researchers modeled the effect of swapping one high-pesticide fruit or vegetable a day for a low-pesticide one, they found 79% higher odds of pregnancy and 88% higher odds of a live birth.

Dr. Yu-Han Chiu, a research fellow in the department of nutrition at the Harvard T.H. Chan School of Public Health and first author of the study told CNN "Although we did find that intake of high-pesticide-residue fruits and vegetables were associated to lower reproductive success, intake of low-pesticide-residue fruits and vegetables had the opposite association."

The researchers agree that the study just show an ‘association’ and more work is needed before a direct ‘causation’ can be established. Also, the results pertain to certain subset of women who already had reproductive issues and were seeking fertility treatment.

The study is accompanied by a commentary by Philip J. Landrigan titled
Pesticides and Human Reproduction


Which fruits you should buy organic
It's not always possible or affordable to buy completely organic produce. Nutritionist Lisa Drayer shows us which fruits to look for in the organic section.
Source: CNN


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Sunday, February 12, 2017

Highest Resolution Images Ever of Eggs, Sperm, and Embryos captured using 5K ultra-HD video.

High resolution image of 5day old human blastocyst 

Morphology is the gold standard by which we can assess the quality of embryos and gametes for success of various fertility treatments.

Imaging science in Reproductive Medicine has not made much significant advances since the last decade. Current options consist of either direct visualization through microscope objectives (limited magnification) or image capture via CCD/CMOS chip and inspection on a monitor (limited resolution).

Doctors attending the recent American Society for Reproductive Medicine’s annual meeting in Salt Lake City, Utah, got the opportunity to visualize first-ever 5K ultra-HD video footage of eggs, sperm, and embryos. It amounts to 14 million pixels per frame, 7 times more than the 1080p Full HD living room television.

The man behind this amazing achievement is Steven F. Palter, MD, a fertility specialist and scientific director at Gold Coast IVF in Woodbury, NY. CDC recently recognized Gold Coast IVF for having highest success rate in USA.

Dr. Palter designed a coupling system to make the RED Camera compatible with an embryo microscope. RED is ultra-high-resolution digital camera company that has revolutionized the movie industry in Hollywood.

860 recordings of eggs, sperm and embryos were made during IVF and ICSI procedures at 400x-960x magnification. The final images then were magnified digitally many times more on 55 inch 4k observation screens, producing the highest magnification and resolution video of these human cells which yielded observations of new cellular details. Movement of individual sperm was observed using high frame that simplified selection.

Dr. Palter said “The images are the sharpest, most revealing images of eggs, sperm, and embryos ever created anywhere. At this level, we are exploring a new frontier of knowledge about human reproduction. It’s an unexplored, uncharted world and we saw new details of the cells never seen before.”

Cellular details and image quality was far superior than what can be viewed with standard microscope. Although, no new structure was identified, the new 5K ultra-HD images could better delineate the morphology of sperms, eggs and embryos for selecting and improving the results of ARTs.

Further validation studies are being carried out currently.

Full text of article in Fertility and Sterility Journal can be accessed here.