Clinical Pearls:
- Higher preconception consumption of Fruits and Vegetable, that have high pesticide residue results in lower probability of livebirth after ART.
American Society for Reproductive
Medicine (ASRM) 2016 Scientific Congress is currently ongoing at
(October 15 – 19) Salt Lake City, Utah. Some selected abstract
and news from the conference.
A prospective cohort study by Chiu Y et
al. examined the association between preconception intake of Fruits and Vegetables(FV)
that has high pesticides residue and outcome of pregnancies conceived by
assisted reproductive techniques. [1]
The study subjects included 300 women
who underwent 493 ART cycles at an academic center between 2007-2015. Food intake was systematically documented by
filling a food questionnaire.
Surveillance data from US Department
of Agriculture was used to classify food into high and low-to-moderate (L-M)
pesticide residues.
Medical records of the academy were
used to provide information on implantation, live birth and clinical pregnancy.
Pregnancy loss was defined as loss after a positive pregnancy test. Linear
regression was used to analyze the result after adjusting for age, BMI, race,
smoking, physical activity, total energy intake, alcohol intake, dietary
patterns, infertility diagnosis and stimulation protocol.
Out of 493 ART cycles,287 women (58%)
had a positive β-hCG with 202 (41%) giving birth to live born infants.
The high pesticide intake was divided
into quartiles based on daily consumption of the Fruits and Vegetables. The highest
probability of live birth per ART was seen in quartile 1-2 (46-47%) whereas the
lowest probability was seen in the 4th quartile (30%). The
association was explained because of higher consumption (≥1.6 servings/d) of FV
by women in 4th quartile as compared to women in the first quartile
who only consumed <0.7 servings/day. (P,trend=0.01).
Consumption of FV with Low to moderate
pesticide residue did not affect the outcome of ART.
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