At least one year is the ideal pregnancy spacing time for the health of mother and baby

  

One to one and a half year is the ideal spacing time between pregnancies according to researchers from the University of British Columbia (B.C.) and the Harvard T.H. Chan School of Public Health.

The study found an increased risk of premature births, maternal morbidity and mortality, and adverse neonatal outcome following an interpregnancy interval of fewer than 12 months in women of all ages. However, women who were 35 or more were at increased risks of maternal mortality or severe morbidity, while women aged 20 to 34 years were at increased risk of preterm labor and adverse fetal and infant outcomes.

In this large cohort study published online October 29 in JAMA Internal Medicine, the researchers looked at data from 148,544 pregnancies in B.C. to examine the relationship between interpregnancy interval and adverse pregnancy. The data was gathered from billing codes, hospitalization data, birth records, prescription data for infertility information, and census records for a period of 10 years (2004 to 2014).

The study is the most extensive and in-depth evaluation of the relationship between pregnancy spacing and maternal age. Currently, it is unknown whether older women face the same risk as younger women because of a shorter interpregnancy interval.

Women aged 35 and more who conceived within six months of a previous birth, faced 1.2 percent risk (12 cases per 1,000 pregnancies) of maternal mortality or severe morbidity (mechanical ventilation, blood transfusion >3 U, intensive care unit admission, and organ failure). Keeping an interpregnancy interval of 18 months, however, reduced the risk to 0.5 percent (five cases per 1,000 pregnancies).

For younger women, who conceived within six months of last childbirth, the researchers found an 8.5 percent risk (85 cases per 1,000 pregnancies) of spontaneous preterm birth, but the risk dropped to 3.7 percent (37 cases per 1,000 pregnancies) if the women waited 18 months before the next conception. 

Among older women, the risk of spontaneous preterm labor was about six percent (60 cases per 1,000 pregnancies) at the six-month interval, compared to 3.4 percent (34 cases per 1,000 pregnancies) at the 18-month interval.

“Our study found increased risks to both mother and infant when pregnancies are closely spaced, including for women older than 35,” said the study’s lead author Laura Schummers in a University of British Columbia news release. Dr. Schummers is a postdoctoral fellow in the UBC department of family practice who carried out the study as part of her dissertation at the Harvard T.H. Chan School of Public Health. “The findings for older women are particularly important, as older women tend to more closely space their pregnancies and often do so intentionally,” she further added. 

Senior author Dr. Wendy Norman, associate professor in the UBC department of family practice, said these findings of a shorter optimal interval are encouraging for women over 35 who are planning their families.

“Older mothers for the first time have excellent evidence to guide the spacing of their children,” said Norman. “Achieving that optimal one-year interval should be doable for many women and is clearly worthwhile to reduce complication risks.”

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Guidelines issued for standardized care to patients with severe hypertension during pregnancy

The National Partnership for Maternal Safety, under the guidance of the Council on Patient Safety in Women’s Health Care, has issued a patient safety bundle that assists the healthcare professionals in providing a standardized care to patients with severe hypertension during pregnancy and the postpartum period.

The consensus  bundle was published online  ahead of print in Journal of Obstetrics and Gynecology. The safety bundle is organized into 4 domains and outlines clinical practices that should be practiced at every maternity unit.

The four domains are: Readiness, Recognition and Prevention, Response, and Reporting and Systems Learning.

Readiness

The readiness domain consists of 5 key components to prepare each maternity unit for prompt and effective management of women with hypertension in pregnancy. It includes:

Each maternity setting should have standardized criteria for recognizing the warning signs, to diagnose, monitor and treat preeclampsia and eclampsia.

The staff should undergo regular drills to practice the protocols.

The maternity unit, along with the OPD and ER should be well equipped for dealing with patients with severe preeclampsia or eclampsia.

All the medications used in emergency treatment should be readily available and stocked continuously.

Appropriate consultations from various concerned department and means of transportation to tertiary center should be available all the time.

Recognition and Prevention

All women should be educated about the warning signs of hypertension in pregnancy.

Standard protocols should be developed for measuring B.P and urine analysis for all women during pregnancy and postpartum period.

Standard protocols should be developed and followed for investigating all women with hypertension in pregnancy. The investigations should include complete blood count with platelets, aspartate transaminase, and alanine transaminase.

Response (Every Case of Severe Hypertension or Preeclampsia)

Each facility should be well equipped with management of severe hypertension, Eclampsia, seizure prophylaxis, and magnesium over dosage and recognizing symptoms of postpartum hypertension.

The concerned physician or primary care provider should be immediately notified if systolic blood pressure is 160 mm Hg or greater or diastolic blood pressure is 110 mm Hg or greater for two measurements within 15 minutes.

If the second blood pressure reading is also high, treatment should be initiated immediately. Guidelines for initiation and maintenance of Magnesium Sulfate should be readily available everywhere.

Escalation measures should be lined out for patients unresponsive to initial treatment along with follow up and education protocols at 7-14 days postpartum.

Reporting and Systems Learning (Every Unit)

All the members of the multidisciplinary team should receive debriefing about the way the emergency was handled, what went well along with areas of improvement.

The team should also review all other patients admitted with severe hypertension and eclampsia about the outcome. Robust data system should be present to report accurate outcomes to all the concerned persons. The review should include all the measures taken since the woman arrived in emergency room till postpartum education and follow-up.

One very important key element in reducing maternal morbidity and mortality and neonatal morbidity and mortality is time to treatment after the recognition of severe hypertension.

The full text of the article can be accessed here.