 |
| Letrozole Tablets |
Letrozole
is an oral non-steroidal aromatase inhibitor approved by US
Food and Drug Administration ( FDA) for the adjuvant treatment
of postmenopausal women with hormone receptor positive early
breast cancer. Off-label it has been used for ovarian stimulation in assisted
reproduction since 2001.
A recent retrospective cohort study
published online November 7, 2016 in Journal of Human Reproduction concluded that
“letrozole stimulation reduces the risk of miscarriage, with no increase in the
risk of major congenital anomalies or adverse pregnancy or neonatal outcomes
compared with natural cycles in women undergoing ART. Letrozole may thus be a
safe option for mild ovarian stimulation.”
The study used data from Japanese
national ART registry between 2011 to 2013. It included 3136
natural cycles and 792 letrozole-induced cycles with, fresh single embryo
transfer resulting in clinical pregnancy were included in the analysis.
The data was analyzed for rates of
ectopic pregnancy, miscarriage and stillbirths as main pregnancy outcomes
while preterm delivery, low birth weight, small/large for gestational age and
major congenital anomalies were neonatal outcomes of primary importance.
After multivariate logistic regression,
it was seen that women who received letrozole had 37% lower odds of miscarriage
(P < 0.001). both groups were comparable for rates of congenital malformations. (natural cycle 1.5% vs letrozole 1.9%, P = 0.52)
No difference in rates of congenital malformations
seen when analyzed for in vitro fertilization or ICSI and early cleavage stage
or blastocyst embryo transfer.
Letrozole was associated with
increased risks of birth defects and has been banned as ovulation induction in
many countries including India since 2011, following reports of 2 studies
citing increase incidences of congenital malformations (locomotor and cardiac
abnormalities). One such study was presented at the American Society ofReproductive Medicine 2005 Conference. [1] But, such off-label use of Letrozole for ovarian stimulation is not illegal in USA and UK.It is still used as an ovulation induction agent in ARTs.
However, The Pregnancy in Polycystic Ovary Syndrome II (PPCOS II) trial results presented
at American Society for Reproductive Medicine (ASRM) 2013 clearly showed that
as compared to clomiphene, ovulation rate, cumulative pregnancy rate and live
birth rate is better for letrozole in patients
with PCOS, and it is not associated with increased risk of pregnancy loss,
multiple pregnancies or adverse effects on fetus.[2]
Subsequently, a review by Roque M et al affirmed the
superiority of letrozole over clomiphene in PCOS patients. [3]
A 2014 Cochranedatabase systemic review also concluded “Letrozole improves live birth and
pregnancy rates in subfertile women with anovulatory PCOS, compared to
clomiphene citrate, though the evidence is low.” [4]
[1] Biljan MM, Hemmings R, Brassard N, et al. The outcome of 150 babies
following treatment with letrozole or letrozole and gonadotropins. Presented at
the American Society for Reproductive Medicine 61st Annual Meeting; October
14-19, 2005; Montreal, Quebec. Abstract O-231.
[2] https://www.ncbi.nlm.nih.gov/pubmed/22265923
[3] https://www.ncbi.nlm.nih.gov/pubmed/26479460
[4] https://www.ncbi.nlm.nih.gov/pubmed/24563180
I understand that etiology of anovulation in cases of all PCOS is not alike. Neither all anovulatory PCOS will response optimally to 4 common types of drugs (e.g., Clomiphene, letrozole group, Insulin sensitizers & Gonadotrophins). The altered cellular dynamics in intracellular & cell membrane receptors are principally falls in three to four major ways. Selecting the right oral OI agent for right women is, understandably a tough job and we commonly go as trial and error basis and thereby admitting some futile cycles. Such a “Hit or Miss attitude”, put a heavy task on Gynecologist specialist & Endocrinologist in particular & loss of morale of the concerned couple.-DR S K Pal, Kolkata drsrimantapal@gmail.com
ReplyDeleteGod bless Dr.CHUKWU MADU for his wonderful work in my life, my name is Helen from USA, I was diagnosed of HERPES since 2016 and it has affected my life i was
Deletetaking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr CHUKWU MADU HERBALHOME how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS delivery company. I took the medicine as prescribed by him and 11 days later i tested negative for HERPES, Dr.CHUKWU MADU truly you are great,It's Good for herpes patient to please read my testimony becuase People think herpes is really a minor skin irritation,herpes has a long term effects on health and The stigma attached to this virus by ignorant people is ridiculous. do you need his help also? Why don't you contact him through his email (dr.chukwumaduherbalhome@gmail.com) or call him on +234703
0936239, DOCTOR CHUKWU MADU CAN AS WELL CURE THE FOLLOWING DISEASE:- 1. HIV/AIDS 2. HERPES 3. CANCER 4. ALS 5. Hepatitis B AND C 6. Diabetes 7. Athrux, 8. hydrophobia 9.hpv 10 pregnancy spell and bring back your ex back 11 scabies 12. STD. 13.Kidney stone?
Selecting the right ovulation INDUCIMG AGENT prior to initiation of class of Ov. Inducing agent??
ReplyDeleteA) Is there any clinical parameters / Laboratory parameter( be it Endoctine ,estimation of enzyme or Growth factor or any other parameter so as to which sub class of anovulatory PCOS will optimally respond without many futile cycles of OI. are best suited for CC and which will be mot benefited by Letrozole, Because mechanism is different. Further which PCOS need Insulin sensitizers or drugs to improve sensitivity can be judged before initiation of Ry?
Dr S K Pal,drsrimantapal@gmail,com
This comment has been removed by a blog administrator.
ReplyDeletehow I was cured from HERPES while this may sound discouraging and people may not belive that HERPES cure has be found,while i was once an HERPES positive i live with this disease for more than years now, i have been to so many places for help including hospitals wasted money and times hoping that i was going to get cure but nor was able, until God use someone to cure me from this disease (HERPES) true the help of a man called Dr OJOGUN with his herbal root herbs medicine. while i don’t have much to say but to give thanks and praise to God almighty who use Sir Dr OJOGUN to extend my life for what you have done for me DR, i will not stop thanking you because you put a smile on my face again,thanks once again if you are into similar problem or with any kind of diseases you can contact Sir Dr OJOGUN on his email {drojogunherbalmedicine@gmail.com} or call him or whatsapp on +2347059015454 and i will not stop thanking you DR OJOGUN for what you have done for me in my life, i will keep posting to the world for them to no that you are in existence , thanks for your audience and i hope you find help like i did for what he has done for me, if you are into similar problem like HERPES,CANCER,DIABETICS.do not waste time to contact him now his WhatsApp +2347059015454 and his email drojogunherbalmedicine@gmail.com
ReplyDeleteI have Genital Herpes for 2 years now and I succeeded in getting rid of it with Herbal medicine, it is natural and fast in curing diseases. To me it is reliable safe and really active. There is no diseases that Herbs don’t have cure to. I was cured from Genital Herpes with Herbal medicine through Dr Onokun Herbal Cure. I came across his good work testimony on You-tube I copied his email address and emailed him I first taught it was a scam not until he sent his Herbal medicine to my country united states.... Email: Dronokunherbalcure@gmail.com
ReplyDeleteI has suffered for Human papillomavirus HPV) for 2years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr onokun is the most trustful herbalist that have herbs to cure wicked symptom's,I emailed dr onokun, for 2weeks been his patient he cured my (HPV) with his herbal. I only used his natural herbs for two weeks it was 100% cure. I'm not (HPV) patient anymore. I'm happy about it i finally got cured out of this mess been in my body for 2years. I also recommend you if you're living with (HPV) or herpes symptoms i also want you to be free contact dr onokun with the email attach to my post. Dronokunherbalcure@gmail.com
ReplyDeleteStaying with Herpes is as easy as you think,but getting the cured seems confusing. I'm so happy because I'm free now from Herpes. I was very unhappy after the checkup and was diagnosed HSV 2 of which I know fully well I can't be cured with the Antibiotics, he prescribed for me the acyclovir(Zovirax), famciclovir (Famvir), andvalacyclovir (Valtrex). These are all taken in pill form. Severe cases may be treated with the intravenous I refuse to try it and went to another clinic for test and it still shows positive. I told the doctor about it and he said it's only by miracle and the prescribed he knows can't cure the virus by only keep fighting so it doesn't replenish always. I wasn't comfortable since I needed the cure.
ReplyDeleteI was in a very sad moon,then I came back in two weeks and still shows the same. I tell you,does who knows understand what I'm saying.
I'm saying this now because my believe leads me to understand that There's a CURE for HERPES.
Of All English medicine you should know God gives us power over all living and non living creatures, don't feel bad now because I know being an Herpes patient for 3 years must have lost hope ,you can still get cure to CANCER, HPV,DIABETES, LOW SPARM COUNT,IRREGULAR OR PAINFUL MENSTRUATION, AND LOSTS HE WILL SHOW YOU AND YOU WILL FEEL THE WAY I DO NOW
IT'S ALL I CAN DO TO HELP IF YOU LOVE TO KNOW
Dr. Odey abang is a very reliable person, don't be scared he can proof to you what you want. Contact him and let him help get cured to all sicknesses.
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@
Email
Odeyabangherbalhome@gmail.com
WhatsApp number@
+2349015049094
I'm morrisons from Alaska
I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com
ReplyDeleteOr Cell Whatsapp Number 2348101755322 thank you .....
I Want To Appreciate Dr.OYAGU for hs great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And Was Look For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have There Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguspellcaster@gmail.com
ReplyDeleteOr Cell Whatsapp Number 2348101755322 thank you .....
May God bless dr.idowu. for his marvelous work in my life, I was diagnosed of HERPES VIRUS, since 2017 and I was taking my medications, I wasn't satisfied with it because i needed to get the{cold score} HERPES VIRUS, Out of my system, I searched about some possible cure for{cold score} Herpes i saw comments about Dr.idowu how he cured people's diseases with his herbal medicine, I contacted him and he guided me. I asked for solutions, he stated the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from {cold score} HERPES, thank you so much and you are the one that God sent to change my miserable life, may the almighty GOD be with you all the days of your life, so my brothers and sisters, I ugh you to contact him on this email address if you need his help Dr.idowuherbalhome@gmail.com .Dr idowu ONCE AGAIN THANK YOU SIR.He also told me that he has solution for the flowing. (+2348052789941) on Whats-app now*fibroid *kidney*fatty liver *HIV/AIDS**..1 Cancer cure Diabetes cures Ringing ear 4 Herpes cures Warts cure HPV cure Get your ex backs Pregnancy herbal medicines Prostate enlargement Hepatitis B 11 Disability Etc. Add him on Whats-app .now add him on via .(+2348052789941) or (+2348052789941). +2348052789941.. .good luck ...save life. you can contract if you have any probelem .............
ReplyDeleteMay God bless dr.idowu. for his marvelous work in my life, I was diagnosed of HERPES VIRUS, since 2017 and I was taking my medications, I wasn't satisfied with it because i needed to get the{cold score} HERPES VIRUS, Out of my system, I searched about some possible cure for{cold score} Herpes i saw comments about Dr.idowu how he cured people's diseases with his herbal medicine, I contacted him and he guided me. I asked for solutions, he stated the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 14 days later i was cured from {cold score} HERPES, thank you so much and you are the one that God sent to change my miserable life, may the almighty GOD be with you all the days of your life, so my brothers and sisters, I ugh you to contact him on this email address if you need his help Dr.idowuherbalhome@gmail.com .Dr idowu ONCE AGAIN THANK YOU SIR.He also told me that he has solution for the flowing. (+2348052789941) on Whats-app now*fibroid *kidney*fatty liver *HIV/AIDS**..1 Cancer cure Diabetes cures Ringing ear 4 Herpes cures Warts cure HPV cure Get your ex backs Pregnancy herbal medicines Prostate enlargement Hepatitis B 11 Disability Etc. Add him on Whats-app .now add him on via .(+2348052789941) or (+2348052789941). +2348052789941.. .good luck ...save life. you can contract if you have any probelem .............
ReplyDeleteI Can't still believe that i got cured from Genital Herpes through herbal treatment from Dr Oyagu who I met through the internet, I actually couldn't believe it at first because it sounded impossible to me knowing how far I have gone just to get rid of it. Dr Oyagu send me his medicine which I took as instructed and here I am living a happy life once again, a big thanks to Dr Oyagu, I am sure there are many herbal doctors out there but Dr Oyagu did it for me, contact him oyaguherbalhome@gmail.com , also call or whatsApp him on +2348101755322
ReplyDeleteI am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com
ReplyDeleteor his WhatApp contact +2348107855231
Can't still believe that i got cured from Genital Herpes through herbal treatment from Dr LUCKY who I met through the internet, I actually couldn't believe it at first because it sounded impossible to me knowing how far I have gone just to get rid of it. Dr LUCKY send me his medicine which I took as instructed and here I am living a happy life once again, a big thanks to Dr LUCKY , I am sure there are many herbal doctors out there but Dr LUCKY did it for me, contact him on Email him; { drluckyherbalcure@gmail.com }
ReplyDeletei visited different hospital but they gave me list of expensive drugs to treat the symptoms and never cured me. A closed friend of mine introduce me to a Herbal Doctor who cured her. I was scared to contact him because of what i experienced from fake doctors. she encouraged me and gave me his whatsapp contact,and i contacted him and i asked him series of questions, i also ask him to show me the results of those he have cured with his herbal drugs,and he gave me all the information i needed that gave me hope. He send a Herbal medicine to me that i took and it seriously worked for me. am now Hepatitis negative. God bless you for being a sincere and great man. Am so excited and am free from herpes virus. you can reach him via email;dralikaherbalhome@gmail.com or whats-app/call on +2348116570358.
ReplyDeleteGod bless Dr.CHUKWU MADU for his wonderful work in my life, my name is Helen from USA, I was diagnosed of HERPES since 2016 and it has affected my life i was
ReplyDeletetaking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr CHUKWU MADU HERBALHOME how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS delivery company. I took the medicine as prescribed by him and 11 days later i tested negative for HERPES, Dr.CHUKWU MADU truly you are great,It's Good for herpes patient to please read my testimony becuase People think herpes is really a minor skin irritation,herpes has a long term effects on health and The stigma attached to this virus by ignorant people is ridiculous. do you need his help also? Why don't you contact him through his email (dr.chukwumaduherbalhome@gmail.com) or call him on +234703
0936239, DOCTOR CHUKWU MADU CAN AS WELL CURE THE FOLLOWING DISEASE:- 1. HIV/AIDS 2. HERPES 3. CANCER 4. ALS 5. Hepatitis B AND C 6. Diabetes 7. Athrux, 8. hydrophobia 9.hpv 10 pregnancy spell and bring back your ex back 11 scabies 12. STD. 13.Kidney stone?
ReplyDeleteIts a miracle that I am alive today. I encounter HERPES SIMPLEX VIRUS (HSV1/2) for good four (4) years, six (6) months and twelve (12) day with my calculations, before I meet the great Dr. Abumere. I am Tina Richard from Fresno California, united state of America and I was affected with herpes virus.Herpes is a viral infection cause by the Herpes simplex virus, marked by painful, watery blister in the skin or mucous membrane or on the genitals. This was what I suffered for good four years. I have visited CVS Pharmacy in Fresno for treatment but no improvement. I meet Dr.Abumere online while I was searching for herpes cure I read a testimony about his work. I give a try that now becomes a testimony in my life. I contacted Dr.Abumere on Email: doctorabumere6@gmail.com or WhatsApp: +2349021975055
I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com
ReplyDeleteor his WhatApp contact +2348110493039
herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with herpes is by taking natural herbs medicine for it and is only few American doctors that know about this herbal medicine from Dr Akhanene .. I have read about Dr Akhanene the great herbalist doctor from African who can cure disease with his powerful herbal medicine. for the people suffering from the following diseases, Herpes, Cancer, Also,Herpatitis, Diabetes, Hps,Infections ETC should contact him for his herbal medicine because i am a living testimony and i was cured of herpes. Although, i sent him what he requested and he sent me his medicine which i took for 1 weeks and today when i went for test i was tested herpes negative. you can reach him through his Emai drakhanenespellhome@gmail.com.com or whatsapp or call him +2348168714427
ReplyDeleteI want to use this opportunity to thank Dr Oyagu for the grate work he has done for me and my cousin sister, I was cured from herpes virus through his herbal remedy and my cousin sisters was also cured from Cancer. This is a grate testimony for what Dr Oyagu Has done for me and my entire generation. I'm giving this testimony so that those of you out there can contact him while he keeps saving my relatives. Send him a Dm and get a better health totally. Contact him via WhatsApp +2348101755322 or Email address:oyaguherbalhome@gmail.com you can also reach him on his website https://oyaguspellcaster.wixsite.com/oyaguherbalhome
ReplyDeleteIf you are reading this and you are suffering from HSV or any other disease or you want to fix your broken marriage/relationship or maybe get back with your Ex husband, Ex wife, Boyfriend or girlfriend.. thanks to__________________ [Robinson.buckler@] yahoo. com
ReplyDelete