Moaza Al
Matrooshi from Dubai, becomes the first woman to give birth to a healthy
baby boy after transplant of her ovarian tissue that was frozen prepubescent at age 9.
Over 60
children have been born to women who have undergone ovarian tissue transplants worldwide,
but all these patients were adults when the ovarian tissue was preserved.
She is at
present 24 and the frozen ovarian tissue was replanted about a year back. Moaza was born with beta thalassemia and
needed bone marrow transplant to save her life.
She had to
have chemotherapy before she was set to receive bone marrow transplant. Her right
ovary was removed cut into strips, frozen, and stored at a hospital in Leeds. It
was mixed with cryoprotective agent and stored at -196 C in liquid nitrogen.
Moaza received
the chemotherapy and bone marrow transplant, but attained a premature menopause
at 20 years of age due to chemotoxicity.
About a year
back surgeons in Denmark replanted five strips of the ovarian tissue back into
her body - four were stitched on to her failed left ovary and one on to the
side of her uterus.
The ovarian
tissue gained blood supply and started functioning as was evident from rising
hormonal levels and evidence of ovulation. Moaza underwent IVF to maximize the
chances of conception.
Two embryos
were transplanted resulting in the birth of healthy baby boy on Tuesday,
December 15 in London at the Portland Hospital for Women and Children.
 |
Moaza
Al Matrooshi with her husband and baby boy: JOE MILES / AFP/GETTY IMAGES
|
The
medical community was overjoyed and celebrated the birth of the boy as it paved
the way to restoring fertility to women who receive chemotherapy at an early age.
Survival rates for children with cancers have reached 90%, but they get the
life back and loose the fertility.
Dr. Sara Matthews
who was Moaza’s obstetrician and gynecologist said "This is a huge step
forward. We know that ovarian tissue transplantation works for older women, but
we've never known if we could take tissue from a child, freeze it and make it
work again. This is moving from an experimental technique to a practical
application."
Scientists
in Leeds were pioneer in performing the world's first transplant of frozen
ovarian tissue back in 1999.
Last year a
woman in Belgium also gave birth after transplant of her ovarian tissue removed
when she was 13 years old and have entered puberty. The first woman in the
world to give birth following the transplantation of her own ovarian tissue in
2004 also happened to be from Belgium.
Sources:
The
mirror,UK
The Guardian
British
Fertility Society
The
Telegraph
American
Cancer Society.
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